Change in urinary myoinositol/citrate ratio associates with progressive loss of renal function in ADPRD patients
Introduction: In autosomal dominant polycystic kidney disease (ADPKD) patients, predicting renal disease progression is important to make a prognosis and to support the clinical decision whether to initiate renoprotective therapy. Conventional markers all have their limitations. Metabolic profiling...
| Published in: | American journal of nephrology Vol. 53, № 6. P. 470-480 |
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| Other Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Online Access: | http://vital.lib.tsu.ru/vital/access/manager/Repository/koha:001000863 Перейти в каталог НБ ТГУ |
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| 024 | 7 | |a 10.1159/000524851 |2 doi | |
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| 040 | |a RU-ToGU |b rus |c RU-ToGU | ||
| 245 | 1 | 0 | |a Change in urinary myoinositol/citrate ratio associates with progressive loss of renal function in ADPRD patients |c S. E. Dekker, A. Verhoeven, D. Frey [et al.] |
| 336 | |a Текст | ||
| 337 | |a электронный | ||
| 504 | |a Библиогр.: 43 назв. | ||
| 520 | 3 | |a Introduction: In autosomal dominant polycystic kidney disease (ADPKD) patients, predicting renal disease progression is important to make a prognosis and to support the clinical decision whether to initiate renoprotective therapy. Conventional markers all have their limitations. Metabolic profiling is a promising strategy for risk stratification. We determined the prognostic performance to identify patients with a fast progressive disease course and evaluated time-dependent changes in urinary metabolites. Methods: Targeted, quantitative metabolomics analysis (H-1 NMR-spectroscopy) was performed on spot urinary samples at two time points, baseline (n = 324, 61% female; mean age 45 years, SD 11; median eGFR 61 mL/min/1.73 m(2), IQR 42-88; mean years of creatinine follow-up 3.7, SD 1.3) and a sample obtained after 3 years of follow-up (n = 112). Patients were stratified by their eGFR slope into fast and slow progressors based on an annualized change of > -3.0 or <= -3.0 mL/min/1.73 m(2)/year, respectively. Fifty-five urinary metabolites and ratios were quantified, and the significant ones were selected. Logistic regression was used to determine prognostic performance in identifying those with a fast progressive course using baseline urine samples. Repeated-measures ANOVA was used to analyze whether changes in urinary metabolites over a 3-year follow-up period differed between fast and slow progressors. Results: In a single urinary sample, the prognostic performance of urinary metabolites was comparable to that of a model including height-adjusted total kidney volume (htTKV, AUC = 0.67). Combined with htTKV, the predictive value of the metabolite model increased (AUC = 0.75). Longitudinal analyses showed an increase in the myoinositol/citrate ratio (p < 0.001) in fast progressors, while no significant change was found in those with slow progression, which is in-line with an overall increase in the myoinositol/citrate ratio as GFR declines. Conclusion: A metabolic profile, measured at a single time point, showed at least equivalent prognostic performance to an imaging-based risk marker in ADPKD. Changes in urinary metabolites over a 3-year follow-up period were associated with a fast progressive disease course. | |
| 653 | |a метаболиты | ||
| 653 | |a моча | ||
| 653 | |a аутосомно-доминантная поликистозная болезнь почек | ||
| 653 | |a расчетная скорость клубочковой фильтрации | ||
| 653 | |a биомаркеры | ||
| 655 | 4 | |a статьи в журналах |9 884122 | |
| 700 | 1 | |a Dekker, Shosha E. I. |9 884121 | |
| 700 | 1 | |a Verhoeven, Aswin |9 814957 | |
| 700 | 1 | |a Frey, Daria |9 884123 | |
| 700 | 1 | |a Soonawala, Darius |9 884124 | |
| 700 | 1 | |a Peters, Dorien J.M. |9 884125 | |
| 700 | 1 | |a Mayboroda, Oleg A. |9 133215 | |
| 700 | 1 | |a Fijter, Johan W. |9 884126 | |
| 773 | 0 | |t American journal of nephrology |d 2022 |g Vol. 53, № 6. P. 470-480 |x 0250-8095 | |
| 852 | 4 | |a RU-ToGU | |
| 856 | 4 | |u http://vital.lib.tsu.ru/vital/access/manager/Repository/koha:001000863 | |
| 856 | |y Перейти в каталог НБ ТГУ |u https://koha.lib.tsu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=1000863 | ||
| 908 | |a статья | ||
| 999 | |c 1000863 |d 1000863 | ||
| 039 | |b 100 | ||