Tumor properties mediate the relationship between peripheral blood monocytes and tumor-associated macrophages in breast cancer

Tumor properties mediate the relationship between peripheral blood monocytes and tumor-associated macrophages in breast cancer

In cancer patients, circulating monocytes show functional alterations. Since monocytes are precursors of tumor-associated macrophages (TAMs), TAMs ensuring tumor viability are potentially replenished through the recruitment of monocytes with specific properties. We demonstrated that locoregional met...

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Bibliographic Details
Published in:Cancer investigation Vol. 40, № 5. P. 442-456
Other Authors: Stakheyeva, Marina N., Patysheva, Marina R., Kaigorodova, Evgeniya V., Zavyalova, Marina V., Tarabanovskaya, Natalia A., Choynzonov, Evgeny L. 1952-, Cherdyntseva, Nadezhda V.
Format: Article
Language:English
Subjects:
рак молочной железы
моноциты
опухолеассоциированные макрофаги
циркулирующие опухолевые клетки
статьи в журналах
Online Access:http://vital.lib.tsu.ru/vital/access/manager/Repository/koha:001003659
Description
Summary:In cancer patients, circulating monocytes show functional alterations. Since monocytes are precursors of tumor-associated macrophages (TAMs), TAMs ensuring tumor viability are potentially replenished through the recruitment of monocytes with specific properties. We demonstrated that locoregional metastasis and circulating factors, such as CD45-EpCAM + CD44 + CD24-/low circulating tumor cells, and serum MCP-1 and HMGB1 were statistically associated with modulation of the monocyte features in breast cancer patients. The count of circulating CD45-EpCAM + cells correlated with CD68+, CD163 + monocyte in blood, and with density of CD68 + TAM in breast cancer tumors. Overall, the relationship between monocytes and TAMs is mediated by the tumor in breast cancer patients.
Bibliography:Библиогр.: 65 назв.
ISSN:0735-7907

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