Tumor properties mediate the relationship between peripheral blood monocytes and tumor-associated macrophages in breast cancer

Tumor properties mediate the relationship between peripheral blood monocytes and tumor-associated macrophages in breast cancer

In cancer patients, circulating monocytes show functional alterations. Since monocytes are precursors of tumor-associated macrophages (TAMs), TAMs ensuring tumor viability are potentially replenished through the recruitment of monocytes with specific properties. We demonstrated that locoregional met...

Full description

Bibliographic Details
Published in:Cancer investigation Vol. 40, № 5. P. 442-456
Other Authors: Stakheyeva, Marina N., Patysheva, Marina R., Kaigorodova, Evgeniya V., Zavyalova, Marina V., Tarabanovskaya, Natalia A., Choynzonov, Evgeny L. 1952-, Cherdyntseva, Nadezhda V.
Format: Article
Language:English
Subjects:
рак молочной железы
моноциты
опухолеассоциированные макрофаги
циркулирующие опухолевые клетки
статьи в журналах
Online Access:http://vital.lib.tsu.ru/vital/access/manager/Repository/koha:001003659
LEADER 02211nab a2200373 c 4500
001 koha001003659
005 20231212184534.0
007 cr |
008 230619|2022 enk s a eng d
024 7 |a 10.1080/07357907.2021.2016803  |2 doi 
035 |a koha001003659 
040 |a RU-ToGU  |b rus  |c RU-ToGU 
245 1 0 |a Tumor properties mediate the relationship between peripheral blood monocytes and tumor-associated macrophages in breast cancer  |c M. N. Stakheyeva, M. R. Patysheva, E. V. Kaigorodova [et al.] 
336 |a Текст 
337 |a электронный 
504 |a Библиогр.: 65 назв. 
520 3 |a In cancer patients, circulating monocytes show functional alterations. Since monocytes are precursors of tumor-associated macrophages (TAMs), TAMs ensuring tumor viability are potentially replenished through the recruitment of monocytes with specific properties. We demonstrated that locoregional metastasis and circulating factors, such as CD45-EpCAM + CD44 + CD24-/low circulating tumor cells, and serum MCP-1 and HMGB1 were statistically associated with modulation of the monocyte features in breast cancer patients. The count of circulating CD45-EpCAM + cells correlated with CD68+, CD163 + monocyte in blood, and with density of CD68 + TAM in breast cancer tumors. Overall, the relationship between monocytes and TAMs is mediated by the tumor in breast cancer patients. 
653 |a рак молочной железы 
653 |a моноциты 
653 |a опухолеассоциированные макрофаги 
653 |a циркулирующие опухолевые клетки 
655 4 |a статьи в журналах 
700 1 |a Stakheyeva, Marina N. 
700 1 |a Patysheva, Marina R. 
700 1 |a Kaigorodova, Evgeniya V. 
700 1 |a Zavyalova, Marina V. 
700 1 |a Tarabanovskaya, Natalia A. 
700 1 |a Choynzonov, Evgeny L.  |d 1952- 
700 1 |a Cherdyntseva, Nadezhda V. 
773 0 |t Cancer investigation  |d 2022  |g Vol. 40, № 5. P. 442-456  |x 0735-7907 
852 4 |a RU-ToGU 
856 4 |u http://vital.lib.tsu.ru/vital/access/manager/Repository/koha:001003659 
908 |a статья 
999 |c 1003659  |d 1003659 

Similar Items