Tumor properties mediate the relationship between peripheral blood monocytes and tumor-associated macrophages in breast cancer
In cancer patients, circulating monocytes show functional alterations. Since monocytes are precursors of tumor-associated macrophages (TAMs), TAMs ensuring tumor viability are potentially replenished through the recruitment of monocytes with specific properties. We demonstrated that locoregional met...
| Published in: | Cancer investigation Vol. 40, № 5. P. 442-456 |
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| Other Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Online Access: | http://vital.lib.tsu.ru/vital/access/manager/Repository/koha:001003659 Перейти в каталог НБ ТГУ |
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| 024 | 7 | |a 10.1080/07357907.2021.2016803 |2 doi | |
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| 245 | 1 | 0 | |a Tumor properties mediate the relationship between peripheral blood monocytes and tumor-associated macrophages in breast cancer |c M. N. Stakheyeva, M. R. Patysheva, E. V. Kaigorodova [et al.] |
| 336 | |a Текст | ||
| 337 | |a электронный | ||
| 504 | |a Библиогр.: 65 назв. | ||
| 520 | 3 | |a In cancer patients, circulating monocytes show functional alterations. Since monocytes are precursors of tumor-associated macrophages (TAMs), TAMs ensuring tumor viability are potentially replenished through the recruitment of monocytes with specific properties. We demonstrated that locoregional metastasis and circulating factors, such as CD45-EpCAM + CD44 + CD24-/low circulating tumor cells, and serum MCP-1 and HMGB1 were statistically associated with modulation of the monocyte features in breast cancer patients. The count of circulating CD45-EpCAM + cells correlated with CD68+, CD163 + monocyte in blood, and with density of CD68 + TAM in breast cancer tumors. Overall, the relationship between monocytes and TAMs is mediated by the tumor in breast cancer patients. | |
| 653 | |a рак молочной железы | ||
| 653 | |a моноциты | ||
| 653 | |a опухолеассоциированные макрофаги | ||
| 653 | |a циркулирующие опухолевые клетки | ||
| 655 | 4 | |a статьи в журналах |9 889084 | |
| 700 | 1 | |a Stakheyeva, Marina N. |9 527865 | |
| 700 | 1 | |a Patysheva, Marina R. |9 806938 | |
| 700 | 1 | |a Kaigorodova, Evgeniya V. |9 102516 | |
| 700 | 1 | |a Zavyalova, Marina V. |9 96115 | |
| 700 | 1 | |a Tarabanovskaya, Natalia A. |9 102518 | |
| 700 | 1 | |a Choynzonov, Evgeny L. |d 1952- |9 106473 | |
| 700 | 1 | |a Cherdyntseva, Nadezhda V. |9 96119 | |
| 773 | 0 | |t Cancer investigation |d 2022 |g Vol. 40, № 5. P. 442-456 |x 0735-7907 | |
| 852 | 4 | |a RU-ToGU | |
| 856 | 4 | |u http://vital.lib.tsu.ru/vital/access/manager/Repository/koha:001003659 | |
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