Mechanisms of the effects of short-term inhalations of Xe and O2 gas mixture in the rehabilitation of post-covid ventilation failure
The article presents a theoretical rationale and a clinical case of relief of post-COVID ventilation failure by inhalation of Xe and O-2 gas mixture. Pneumonitis of coronavirus etiology transforms saturated phospholipids of surfactant into a solid-ordered phase, which disrupts surface tension, alveo...
| Опубликовано в: : | Bulletin of experimental biology and medicine Vol. 172, № 3. P. 364-367 |
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| Другие авторы: | , , , , , , |
| Формат: | Статья в журнале |
| Язык: | English |
| Предметы: | |
| Online-ссылка: | http://vital.lib.tsu.ru/vital/access/manager/Repository/koha:001004091 Перейти в каталог НБ ТГУ |
| Итог: | The article presents a theoretical rationale and a clinical case of relief of post-COVID ventilation failure by inhalation of Xe and O-2 gas mixture. Pneumonitis of coronavirus etiology transforms saturated phospholipids of surfactant into a solid-ordered phase, which disrupts surface tension, alveolar pneumatization, and alveolar-capillary gas exchange. Using molecular modeling (B3LYP/lanl2dz; GAUSSIAN09), we demonstrated that Xe atom due to the van der Waals dispersion interaction increases the distance between the phospholipid acyl chains providing a phase transition from the solid-ordered to liquid phase and restored the surface-active monolayer surfactant film. A clinical case confirmed that short-term inhalations of the Xe and O-2 gas mixture relieved manifestations of ventilation insufficiency and increased SpO(2) and pneumatization of the terminal parts of the lungs. |
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| Библиография: | Библиогр.: 15 назв. |
| ISSN: | 0007-4888 |