Mechanisms of the effects of short-term inhalations of Xe and O2 gas mixture in the rehabilitation of post-covid ventilation failure

Mechanisms of the effects of short-term inhalations of Xe and O2 gas mixture in the rehabilitation of post-covid ventilation failure

The article presents a theoretical rationale and a clinical case of relief of post-COVID ventilation failure by inhalation of Xe and O-2 gas mixture. Pneumonitis of coronavirus etiology transforms saturated phospholipids of surfactant into a solid-ordered phase, which disrupts surface tension, alveo...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine Vol. 172, № 3. P. 364-367
Other Authors: Udut, Vladimir V., Naumov, Sergei Alexandrovich, Udut, Elena V., Naumov, Sergei Sergeevich, Evtushenko, Diana Nikolaevna, Chumakova, O. N., Zyuzkov, Gleb N.
Format: Article
Language:English
Subjects:
постковидные осложнения
легочный сурфактант
дипальмитоилфосфатидилхолин
молекулярный электростатический потенциал
ингаляции газовой смесью ксенона и кислорода
статьи в журналах
Online Access:http://vital.lib.tsu.ru/vital/access/manager/Repository/koha:001004091
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520 3 |a The article presents a theoretical rationale and a clinical case of relief of post-COVID ventilation failure by inhalation of Xe and O-2 gas mixture. Pneumonitis of coronavirus etiology transforms saturated phospholipids of surfactant into a solid-ordered phase, which disrupts surface tension, alveolar pneumatization, and alveolar-capillary gas exchange. Using molecular modeling (B3LYP/lanl2dz; GAUSSIAN09), we demonstrated that Xe atom due to the van der Waals dispersion interaction increases the distance between the phospholipid acyl chains providing a phase transition from the solid-ordered to liquid phase and restored the surface-active monolayer surfactant film. A clinical case confirmed that short-term inhalations of the Xe and O-2 gas mixture relieved manifestations of ventilation insufficiency and increased SpO(2) and pneumatization of the terminal parts of the lungs. 
653 |a постковидные осложнения 
653 |a легочный сурфактант 
653 |a дипальмитоилфосфатидилхолин 
653 |a молекулярный электростатический потенциал 
653 |a ингаляции газовой смесью ксенона и кислорода 
655 4 |a статьи в журналах 
700 1 |a Udut, Vladimir V. 
700 1 |a Naumov, Sergei Alexandrovich 
700 1 |a Udut, Elena V. 
700 1 |a Naumov, Sergei Sergeevich 
700 1 |a Evtushenko, Diana Nikolaevna 
700 1 |a Chumakova, O. N. 
700 1 |a Zyuzkov, Gleb N. 
773 0 |t Bulletin of experimental biology and medicine  |d 2022  |g Vol. 172, № 3. P. 364-367  |x 0007-4888 
852 4 |a RU-ToGU 
856 4 |u http://vital.lib.tsu.ru/vital/access/manager/Repository/koha:001004091 
908 |a статья 
999 |c 1004091  |d 1004091 

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