Характеристика транскриптома циркулирующих моноцитов при раке молочной железы
Circulating monocytes are the main source of tumor-associated macrophages. It has been shown that blood monocytes can have certain transcriptional, epigenetic, and metabolic programs mediated by the presence of solid carcinomas. On the other hand, monocytes are direct participants in inflammation, w...
| Опубликовано в: : | Перспективы развития фундаментальных наук. Т. 4 : сборник научных трудов XIX Международной конференции студентов, аспирантов и молодых ученых, 26-29 апреля 2022 г. Т. 4 : Биология и фундаментальная медицина. С. 56-58 |
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| Главный автор: | |
| Другие авторы: | , |
| Формат: | Статья в сборнике |
| Язык: | Russian |
| Предметы: | |
| Online-ссылка: | http://vital.lib.tsu.ru/vital/access/manager/Repository/koha:001007272 Перейти в каталог НБ ТГУ |
| Итог: | Circulating monocytes are the main source of tumor-associated macrophages. It has been shown that blood monocytes can have certain transcriptional, epigenetic, and metabolic programs mediated by the presence of solid carcinomas. On the other hand, monocytes are direct participants in inflammation, which is a significant pathogenetic factor in neoplasia. The aim of the research was to investigate the extent to which the transcriptome profile of monocytes is associated with the presence of breast cancer (BC) and whether the obtained data can be of clinical value. It was found that the transcriptome of monocytes in BC differs from the transcriptome of monocytes of healthy women for the CD14+ cells. 31 genes were also identified with overexpression with adj.p.val<0.05 and log2FC≥0.75 in monocytes in BC. Data were obtained on a significant increase in the level of transcripts of the ABCA1, DDIT4, PLIN1 and CXCR4 genes in BC group during the validation of the results of the monocyte transcriptome. |
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| Библиография: | Библиогр.: 3 назв. |
| ISBN: | 9785438710851 9785438710813 |