|
|
|
|
| LEADER |
02848naa a2200325 c 4500 |
| 001 |
koha001007273 |
| 005 |
20231201132543.0 |
| 007 |
cr | |
| 008 |
231006s2022 ru fs 100 0 rus d |
| 035 |
|
|
|a koha001007273
|
| 040 |
|
|
|a RU-ToGU
|b rus
|c RU-ToGU
|
| 100 |
1 |
|
|a Ракина, Милица Александровна
|
| 245 |
1 |
0 |
|a Анализ генного профиля клеток аденокарциномы кишечника и макрофагов, выращенных в ко-культуре, в ответ на химиотерапию in vitro
|c М. А. Ракина, Е. О. Казакова, И. В. Ларионова
|
| 246 |
1 |
1 |
|a Gene expression profiling of colorectal adenocarcinoma cells and macrophages grown in co-culture in response to chemotherapy in vitro
|
| 336 |
|
|
|a Текст
|
| 337 |
|
|
|a электронный
|
| 504 |
|
|
|a Библиогр.: 2 назв.
|
| 520 |
3 |
|
|a Colorectal cancer (CRC) is one of the most common and fatal malignancies in the world [1]. Tumor associated macrophages (TAM) are key cells of innate immunity and in tumor microenvironment that constitute up to 50% of cells and play a crucial role in tumor progression [2]. Chemotherapy (CT) is considered as one of the main types of anticancer treatment for solid tumors. However, in colon cancer its effectiveness is hindered due to various reasons, one of them being TAMs. In particular, their involvement in tumor response to CT or more accurately lack thereof [2]. Thus, we studied gene expression profile of monocyte-derived TAMs from CRC patients and adenocarcinoma cancer cells grown in coculture for the presence of markers of M2 polarization, epithelial-mesenchymal transition, angiogenesis and invasion in response to stimulation with various chemotherapy anticancer drugs in vitro.
|
| 653 |
|
|
|a колоректальный рак
|
| 653 |
|
|
|a опухолессоциированные макрофаги
|
| 653 |
|
|
|a противоопухолевая терапия
|
| 653 |
|
|
|a экспериментальные исследования
|
| 655 |
|
4 |
|a статьи в сборниках
|
| 700 |
1 |
|
|a Казакова, Елена Олеговна
|
| 700 |
1 |
|
|a Ларионова, Ирина Валерьевна
|
| 773 |
0 |
|
|t Перспективы развития фундаментальных наук. Т. 4 : сборник научных трудов XIX Международной конференции студентов, аспирантов и молодых ученых, 26-29 апреля 2022 г.
|d Томск, 2022
|g Т. 4 : Биология и фундаментальная медицина. С. 59-61
|z 9785438710851
|z 9785438710813
|
| 852 |
4 |
|
|a RU-ToGU
|
| 856 |
4 |
|
|u http://vital.lib.tsu.ru/vital/access/manager/Repository/koha:001007273
|
| 908 |
|
|
|a статья
|
| 999 |
|
|
|c 1007273
|d 1007273
|