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|a Раченков, Кирилл Андреевич
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|a Определение экспрессионного профиля фосфатаз двойной специфичности (DUSP) в моноцитах пациентов с колоректальным раком
|c К. А. Раченков, П. С. Ямщиков, М. С. Дорофеева
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|a Expression profile of dual specifity phosphatase (DUSP) in monocytes from patients with colorectal cancer
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|a Текст
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|a электронный
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|a Библиогр.: 4 назв.
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|a Circulating monocytes are an important component of the body's nonspecific immunity. Those cells are the main source of formation of tumor-associated macrophages (TAM). Сcurrently known that the variety of inflammation options in tumor tissue is due to the predominant development of different types of immune responses in it, which are associated with pro- or antitumor differentiation of macrophages. To maintain a controlled and balanced course of the immune response, a clear and well-coordinated work of the cascades of activation and phosphorylation of kinases that regulate the activation of protective cells is required. The dualspecific phosphatase (DUSP) gene family includes several enzyme subtypes that are expressed differently in resting and activated immune cells. They control the duration and intensity of phosphorylation signals. The study of DUSP gene expression and transcriptome in monocytes of patients with oncological diseases seems to be a promising direction in oncoimmunology. The aim of this work is to study the expression profile of DUSP in patients with colorectal cancer and in patients without this pathology. The aim of the experiment was also to study the transcriptome of monocytes and to identify differences between groups. During the analysis, it was found that the monocyte fraction in both patients and healthy women was represented by 3 cell clusters, each of which contained transcripts of the DUSP family genes. Regardless of the study groups, DUSP1, DUSP6, were detected in significant amounts, which indicates their functional significance for monocytes. Elucidation of the role of DUSP in the regulation of the immune response of cells in the future can be used for its targeted
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|a опухолеассоциированные макрофаги
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|a колоректальный рак
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|a экспериментальные исследования
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|a фосфатазы с двойной специфичностью
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|a статьи в сборниках
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|a Ямщиков, Павел Сергеевич
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|a Дорофеева, Мария Сергеевна
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|t Перспективы развития фундаментальных наук. Т. 4 : сборник научных трудов XIX Международной конференции студентов, аспирантов и молодых ученых, 26-29 апреля 2022 г.
|d Томск, 2022
|g Т. 4 : Биология и фундаментальная медицина. С. 62-65
|z 9785438710851
|z 9785438710813
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|a RU-ToGU
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|u http://vital.lib.tsu.ru/vital/access/manager/Repository/koha:001007276
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|a статья
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|d 1007276
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