Screening of Alzheimer’s disease with multiwavelength stokes polarimetry in a mouse model

Screening of Alzheimer’s disease with multiwavelength stokes polarimetry in a mouse model

The minimum histological criterion for the diagnostics of Alzheimer's disease (AD) in tissue is the presence of senile plaques and neurofibrillary tangles in specific brain locations. The routine procedure of morphological analysis implies time-consuming and laborious steps including sectioning...

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Bibliographic Details
Published in:IEEE transactions on medical imaging Vol. 41, № 4. P. 977-982
Other Authors: Borovkova, Mariia, Sieryi, Oleksii, Lopushenko, Ivan, Kartashkina, Natalia, Pahnke, Jens, Bykov, Alexander V., Meglinski, Igor V.
Format: Article
Language:English
Subjects:
оптическая поляриметрия
рассеяние
двулучепреломление
Альцгеймера болезнь
скрининг
Стокса вектор
многоволновая поляриметрия
мыши
статьи в журналах
Online Access:http://vital.lib.tsu.ru/vital/access/manager/Repository/koha:001007865
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245 1 0 |a Screening of Alzheimer’s disease with multiwavelength stokes polarimetry in a mouse model  |c M. Borovkova, O. Sieryi, I. Lopushenko [et al.] 
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520 3 |a The minimum histological criterion for the diagnostics of Alzheimer's disease (AD) in tissue is the presence of senile plaques and neurofibrillary tangles in specific brain locations. The routine procedure of morphological analysis implies time-consuming and laborious steps including sectioning and staining of formalin-fixed paraffin-embedded (FFPE) tissue. We developed a multi-spectral Stokes polarimetric imaging approach that allows characterization of FFPE brain tissue samples to discern the stages of AD progression without sectioning and staining the tissue. The Stokes polarimetry approach is highly sensitive to structural alterations of brain tissue, particularly to the changes in light scattering and birefringence. We present the results of the label-free non-destructive screening of FFPE mouse brain tissue and show several polarization metrics that demonstrate statistically significant differences for tissues at different stages of AD. 
653 |a оптическая поляриметрия 
653 |a рассеяние 
653 |a двулучепреломление 
653 |a Альцгеймера болезнь 
653 |a скрининг 
653 |a Стокса вектор 
653 |a многоволновая поляриметрия 
653 |a мыши 
655 4 |a статьи в журналах 
700 1 |a Borovkova, Mariia 
700 1 |a Sieryi, Oleksii 
700 1 |a Lopushenko, Ivan 
700 1 |a Kartashkina, Natalia 
700 1 |a Pahnke, Jens 
700 1 |a Bykov, Alexander V. 
700 1 |a Meglinski, Igor V. 
773 0 |t IEEE transactions on medical imaging  |d 2022  |g Vol. 41, № 4. P. 977-982  |x 0278-0062 
852 4 |a RU-ToGU 
856 4 |u http://vital.lib.tsu.ru/vital/access/manager/Repository/koha:001007865 
908 |a статья 
999 |c 1007865  |d 1007865 

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