Adaptive oncogenesis a new understanding of how cancer evolves inside us
"Popular understanding holds that genetic changes create cancer. James DeGregori uses evolutionary principles to propose a new way of thinking about cancer's occurrence. Cancer is as much a disease of evolution as it is of mutation, one in which mutated cells outcompete healthy cells in th...
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| Format: | eBook |
| Language: | English |
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Cambridge, Massachusetts
Harvard University Press,
2018.
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| Online Access: | https://www.lib.tsu.ru/mminfo/2023/EBSCO/1712989.pdf |
Table of Contents:
- The evolution of lifespans and disease avoidance
- Understanding evolution at organismal and somatic levels
- The evolution of multicellularity and tumor suppression
- Mechanisms of tumor suppression
- Dominant views on the mechanisms of oncogenesis
- Adaptive oncogenesis
- Limiting somatic evolution in youth
- Changing adaptive landscapes in aging tissues
- Changing adaptive landscapes with carcinogenic exposures
- Tissue architecture and tumor suppression
- Peto's paradox
- Prolonging tissue maintenance to delay aging and cancer
- Understanding clinical data from an evolutionary perspective
- The causes of cancer in early childhood
- Evolution-informed strategies to combat cancer
- A new framework for understanding and controlling cancer.