Protein tyrosine phosphatases structure, signaling and drug discovery
Protein tyrosine phosphatases remove phosphates from the phosphotyrosine residues of target proteins and reverse the action of various protein tyrosine kinases. This essential interplay between the opposing actions of protein tyrosine phosphatases and protein tyrosine kinases forms the basis of sign...
| Main Author: | |
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| Format: | eBook |
| Language: | English |
| Published: |
Berlin ; Boston
De Gruyter,
[2018]
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| Subjects: | |
| Online Access: | EBSCOhost Перейти в каталог НБ ТГУ |
| LEADER | 04260cam a2200541Mi 4500 | ||
|---|---|---|---|
| 001 | koha001011191 | ||
| 003 | OCoLC | ||
| 005 | 20250222065834.0 | ||
| 006 | m d | ||
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| 008 | 181023t20182018gw fobd z001 0 eng d | ||
| 035 | |a koha001011191 | ||
| 040 | |a DEGRU |b eng |e rda |c DEGRU |d EBLCP |d YDXIT |d N$T |d CNCGM | ||
| 020 | |a 3110421771 |q electronic book | ||
| 020 | |a 9783110421774 |q (electronic bk.) | ||
| 024 | 7 | |a 10.1515/9783110421774 |2 doi | |
| 044 | |a gw |c DE | ||
| 050 | 4 | |a QP609.P56 |b A38 2018 | |
| 072 | 7 | |a SCI007000 |2 bisacsh | |
| 072 | 7 | |a SCI013000 |2 bisacsh | |
| 072 | 7 | |a SCI013020 |2 bisacsh | |
| 072 | 7 | |a SCI013050 |2 bisacsh | |
| 072 | 7 | |a SCI |x 007000 |2 bisacsh | |
| 082 | 0 | 4 | |a 572/.68 |2 23 |
| 049 | |a MAIN | ||
| 100 | 1 | |a Ahuja, Lalima G., |9 906477 | |
| 245 | 1 | 0 | |a Protein tyrosine phosphatases |b structure, signaling and drug discovery |c Lalima G. Ahuja. |
| 264 | 1 | |a Berlin ; |a Boston |b De Gruyter, |c [2018] | |
| 300 | |a 1 online resource (xiv, 282 pages) | ||
| 347 | |a text file |b PDF |2 rda | ||
| 504 | |a Includes bibliographical references and index. | ||
| 505 | 0 | 0 | |t Frontmatter -- |t Preface -- |t About The Author -- |t Contents -- |t 1.Tyrosine Phosphorylation In Cell Signaling: Discovery And Beyond -- |t 2.Protein Phosphatases: Classification And Domain Architecture -- |t 3.Protein Tyrosine Phosphatases: Molecular Structure And Mechanism -- |t 4.The Receptor Protein Tyrosine Phosphatases: Structure And Function -- |t 5.The Double-Domain Receptor Protein Tyrosine Phosphatases -- |t 6 The Non-Receptor Protein Tyrosine Phosphatases: Part I -- |t 7.The Non-Receptor Protein Tyrosine Phosphatases: Part Ii -- |t 8.Protein Tyrosine Phosphatases: Strategies For Drug Development -- |t Index |
| 520 | |a Protein tyrosine phosphatases remove phosphates from the phosphotyrosine residues of target proteins and reverse the action of various protein tyrosine kinases. This essential interplay between the opposing actions of protein tyrosine phosphatases and protein tyrosine kinases forms the basis of signaling networks that underlie the cellular workings of human physiology. Initially passed-off as housekeeping genes; these proteins were only acknowledged to maintain a steady background of phosphotyrosine levels in the cell. However, recent progress in studying their role in embryonic development and human disease has established their importance as regulators of signal regulation. Convincing evidence shows the role of mutations in these proteins to cause and/or intensify the severity of various diseases including metabolic and neurological disorders and also cancer. Protein tyrosine phosphatases have slowly, yet convincingly become crucial targets for therapeutic intervention of various human pathophysiologies. This book describes these signaling enzymes using the molecular details of their structure and mechanistic function. Various subtypes of cysteine-based Class I, II, III and the Haloacid dehalogenase related Class IV protein tyrosine phosphatases have been illustrated and explained. The superfamily of proteins is also described vis-a-vis its complimentary protein phosphoserine/phosphoserine phosphatases. Membrane bound receptor forms and the cytosolic non-receptor protein tyrosine phosphatases have been described for their biological function. This book serves as a reference for any reader looking to understand the sequence features, structural elements, molecular mechanism and cellular function of this superfamily of signaling enzymes. | ||
| 588 | 0 | |a Description based on online resource; title from PDF title page (publisher's Web site, viewed 23. Okt 2018). | |
| 653 | 0 | |a Protein-tyrosine phosphatase. | |
| 653 | 4 | |a Biochemie. | |
| 653 | 4 | |a Medizinische Chemie. | |
| 653 | 4 | |a Proteintyrosinphosphatase. | |
| 653 | 4 | |a Signalproteine. | |
| 653 | 4 | |a Wirkstoffdesign. | |
| 653 | 7 | |a SCIENCE / Life Sciences / Biochemistry |2 bisacsh | |
| 655 | 0 | |a EBSCO eBooks |9 905790 | |
| 655 | 4 | |a Electronic books. |9 899821 | |
| 856 | 4 | 0 | |3 EBSCOhost |u https://www.lib.tsu.ru/limit/2023/EBSCO/1913015.pdf |
| 856 | |y Перейти в каталог НБ ТГУ |u https://koha.lib.tsu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=1011191 | ||
| 910 | |a EBSCO eBooks | ||
| 999 | |c 1011191 |d 1011191 | ||
| 039 | |||