Multicomponent synthesis of unsymmetrical derivatives of 4-methyl-substituted 5-nitropyridines
The multicomponent reaction of 2-nitroacetophenone (or nitroacetone), acetaldehyde diethyl acetal, β-dicarbonyl compound, and ammonium acetate in an acetic acid solution allowed the acquisition of previously undescribed 4-methyl-substituted derivatives of 5-nitro-1,4-dihydropyridine in satisfactory...
| Опубликовано в: : | Processes Vol. 11, № 2. P. 576 (1-12) |
|---|---|
| Другие авторы: | , , , , , , |
| Формат: | Статья в журнале |
| Язык: | English |
| Предметы: | |
| Online-ссылка: | http://vital.lib.tsu.ru/vital/access/manager/Repository/koha:001133165 Перейти в каталог НБ ТГУ |
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| 008 | 240411|2023 sz s a eng d | ||
| 024 | 7 | |a 10.3390/pr11020576 |2 doi | |
| 035 | |a koha001133165 | ||
| 040 | |a RU-ToGU |b rus |c RU-ToGU | ||
| 245 | 1 | 0 | |a Multicomponent synthesis of unsymmetrical derivatives of 4-methyl-substituted 5-nitropyridines |c D. M. Turgunalieva, A. L. Stalinskaya, I. I. Kulakov [et al.] |
| 336 | |a Текст | ||
| 337 | |a электронный | ||
| 504 | |a Библиогр.: 76 назв. | ||
| 520 | 3 | |a The multicomponent reaction of 2-nitroacetophenone (or nitroacetone), acetaldehyde diethyl acetal, β-dicarbonyl compound, and ammonium acetate in an acetic acid solution allowed the acquisition of previously undescribed 4-methyl-substituted derivatives of 5-nitro-1,4-dihydropyridine in satisfactory yields. The oxidation of the obtained 5-nitro-1,4-dihydropyridine derivatives resulted in the corresponding 2,4-dimethyl-5-nitropyridines. In addition, for the first time in the synthesis of unsymmetrical 1,4-dihydropyridines by the Hantzsch reaction acetaldehyde, diethyl acetal was used as a source of acetaldehyde. The use of more volatile and sufficiently reactive acetaldehyde in this reaction did not lead to a controlled synthesis of unsymmetrical 5-nitro-1,4-dihydropyridines. The proposed multicomponent approach to the synthesis of 4-methyl-substituted 5-nitro-1,4-dihydropyridines and their subsequent aromatization into pyridines made it possible to obtain previously undescribed and hardly accessible substituted 5(3)-nitropyridines. | |
| 653 | |a 2-нитроацетофенон | ||
| 653 | |a нитроацетон | ||
| 653 | |a ацетальдегид диэтилацеталь | ||
| 653 | |a 5(3)-нитро-1,4-дигидропиридины | ||
| 653 | |a 5(3)-нитропиридины | ||
| 653 | |a зеленая химия | ||
| 653 | |a многокомпонентные реакции | ||
| 653 | |a β-дикарбонильные соединения | ||
| 655 | 4 | |a статьи в журналах |9 957415 | |
| 700 | 1 | |a Turgunalieva, Daria M. |9 957414 | |
| 700 | 1 | |a Stalinskaya, Alena L. |9 957416 | |
| 700 | 1 | |a Kulakov, Ilya I. |9 957417 | |
| 700 | 1 | |a Sagitullina, Galina P. |9 957418 | |
| 700 | 1 | |a Atuchin, Victor V. |9 95830 | |
| 700 | 1 | |a Elyshev, Andrey V. |9 957419 | |
| 700 | 1 | |a Kulakov, Ivan V. |9 957420 | |
| 773 | 0 | |t Processes |d 2023 |g Vol. 11, № 2. P. 576 (1-12) |x 2227-9717 | |
| 852 | 4 | |a RU-ToGU | |
| 856 | 4 | |u http://vital.lib.tsu.ru/vital/access/manager/Repository/koha:001133165 | |
| 856 | |y Перейти в каталог НБ ТГУ |u https://koha.lib.tsu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=1133165 | ||
| 908 | |a статья | ||
| 999 | |c 1133165 |d 1133165 | ||
| 039 | |b 100 | ||