Heteroaromatic Lipoxin A4 Analogues Synthesis and Biological Evaluation /
In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines kno...
| Published in: | Springer eBooks |
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| Format: | eBook |
| Language: | English |
| Published: |
Berlin, Heidelberg :
Springer Berlin Heidelberg,
2012.
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| Series: | Springer Theses
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| Subjects: | |
| Online Access: | http://dx.doi.org/10.1007/978-3-642-24632-6 Перейти в каталог НБ ТГУ |
| Summary: | In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in the synthesis of further heteroaromatic analogues for biological evaluation. |
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| Physical Description: | XXII, 130 p. online resource. |
| ISBN: | 9783642246326 |