Deconvoluting hepatic processing of carbon nanotubes
Single-wall carbon nanotubes present unique opportunities for drug delivery, but have not advanced into the clinic. Differential nanotube accretion and clearance from critical organs have been observed, but the mechanism not fully elucidated. The liver has a complex cellular composition that regulat...
| Published in: | Nature communications Vol. 7. P. 12343 (1-11) |
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| Other Authors: | , , , , , , , , , , , , , , , , , |
| Format: | Article |
| Language: | Russian |
| Subjects: | |
| Online Access: | http://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000576659 Перейти в каталог НБ ТГУ |
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| 024 | 7 | |a 10.1038/ncomms12343 |2 doi | |
| 035 | |a to000576659 | ||
| 039 | 9 | |a 201706010851 |c 201705311825 |d VLOAD |y 201705311305 |z Александр Эльверович Гилязов | |
| 040 | |a RU-ToGU |b rus |c RU-ToGU | ||
| 245 | 1 | 0 | |a Deconvoluting hepatic processing of carbon nanotubes |c S. Alidori, R. L. Bowman, D. Yarilin [et.al.] |
| 504 | |a Библиогр.: 59 назв. | ||
| 520 | 3 | |a Single-wall carbon nanotubes present unique opportunities for drug delivery, but have not advanced into the clinic. Differential nanotube accretion and clearance from critical organs have been observed, but the mechanism not fully elucidated. The liver has a complex cellular composition that regulates a range of metabolic functions and coincidently accumulates most particulate drugs. Here we provide the unexpected details of hepatic processing of covalently functionalized nanotubes including receptor-mediated endocytosis, cellular trafficking and biliary elimination. Ammonium-functionalized fibrillar nanocarbon is found to preferentially localize in the fenestrated sinusoidal endothelium of the liver but not resident macrophages. Stabilin receptors mediate the endocytic clearance of nanotubes. Biocompatibility is evidenced by the absence of cell death and no immune cell infiltration. Towards clinical application of this platform, nanotubes were evaluated for the first time in non-human primates. The pharmacologic profile in cynomolgus monkeys is equivalent to what was reported in mice and suggests that nanotubes should behave similarly in humans. | |
| 653 | |a углеродные нанотрубки | ||
| 653 | |a печень | ||
| 653 | |a применение в медицине | ||
| 655 | 4 | |a статьи в журналах |9 879358 | |
| 700 | 1 | |a Alidori, Simone |9 411545 | |
| 700 | 1 | |a Yarilin, Dmitry |9 411546 | |
| 700 | 1 | |a Romin, Yevgeniy |9 411547 | |
| 700 | 1 | |a Barlas, Afsar |9 411548 | |
| 700 | 1 | |a Mulvey, J. Justin |9 411549 | |
| 700 | 1 | |a Fujisawa, Sho |9 411550 | |
| 700 | 1 | |a Xu, Ke |9 411551 | |
| 700 | 1 | |a Ruggiero, Alessandro |9 411552 | |
| 700 | 1 | |a Riabov, Vladimir B. |9 105457 | |
| 700 | 1 | |a Bowman, Robert L. |9 411553 | |
| 700 | 1 | |a Thorek, Daniel L. J. |9 411554 | |
| 700 | 1 | |a Ulmert, Hans David S. |9 411555 | |
| 700 | 1 | |a Brea, Elliott J. |9 411556 | |
| 700 | 1 | |a Behling, Katja |9 411557 | |
| 700 | 1 | |a Kzhyshkowska, Julia G. |9 102999 | |
| 700 | 1 | |a Manova-Todorova, Katia |9 411558 | |
| 700 | 1 | |a Scheinberg, David A. |9 411559 | |
| 700 | 1 | |a McDevitt, Michael R. |9 411560 | |
| 773 | 0 | |t Nature communications |d 2016 |g Vol. 7. P. 12343 (1-11) |x 2041-1723 | |
| 852 | 4 | |a RU-ToGU | |
| 856 | 7 | |u http://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000576659 | |
| 856 | |y Перейти в каталог НБ ТГУ |u https://koha.lib.tsu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=354896 | ||
| 908 | |a статья | ||
| 999 | |c 354896 |d 354896 | ||