Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds
The author has developed novel methodologies for highly efficient construction of functionalized heterocycles by palladium-catalyzed domino/cascade cyclization of allenes and related compounds containing appropriate nucleophilic group(s). Based on these methodologies, enantioselective total synthese...
| Published in: | Springer eBooks |
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| Main Author: | |
| Corporate Author: | |
| Format: | eBook |
| Language: | English |
| Published: |
Tokyo :
Springer Tokyo,
2012.
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| Series: | Springer Theses
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| Subjects: | |
| Online Access: | http://dx.doi.org/10.1007/978-4-431-54043-4 Перейти в каталог НБ ТГУ |
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| 039 | 9 | |y 201407111547 |z Александр Эльверович Гилязов | |
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| 100 | 1 | |a Inuki, Shinsuke. |e author. |9 412262 | |
| 245 | 1 | 0 | |a Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds |h electronic resource |c by Shinsuke Inuki. |
| 260 | |a Tokyo : |b Springer Tokyo, |c 2012. |9 742225 | ||
| 300 | |a XVI, 106 p. |b online resource. | ||
| 336 | |a text |b txt |2 rdacontent | ||
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| 490 | 1 | |a Springer Theses | |
| 505 | 0 | |a Chapter 1. Total Synthesis of Pachastrissamine (Jaspine B) -- Chapter 2. Total Synthesis of Lysergic Acid, Lysergol, and Isolysergol -- Chapter 3. Conclusions. | |
| 520 | |a The author has developed novel methodologies for highly efficient construction of functionalized heterocycles by palladium-catalyzed domino/cascade cyclization of allenes and related compounds containing appropriate nucleophilic group(s). Based on these methodologies, enantioselective total syntheses of bioactive natural products, pachastrissamine (26% overall yield in seven steps), lysergic acid (4.0% overall yield in fifteen steps), lysergol (3.6% overall yield in fifteen steps) and isolysergol (8.2% overall yield in eleven steps) have been achieved. These are more facile synthetic route than those previously reported. These findings would contribute to the development of efficient synthetic methods for biologically active compounds containing a complex structure. | ||
| 650 | 0 | |a chemistry. |9 161768 | |
| 650 | 0 | |a Bioorganic chemistry. |9 566455 | |
| 650 | 0 | |a Catalysis. |9 308199 | |
| 650 | 1 | 4 | |a Chemistry. |9 161768 |
| 650 | 2 | 4 | |a Bioorganic Chemistry. |9 566456 |
| 650 | 2 | 4 | |a Catalysis. |9 308199 |
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| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/978-4-431-54043-4 |
| 856 | |y Перейти в каталог НБ ТГУ |u https://koha.lib.tsu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=355502 | ||
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