Cholesterol and Presynaptic Glutamate Transport in the Brain
Glutamate is the primary excitatory neurotransmitter in the CNS and disturbances in glutamate transport contribute to a number of neurological and neurodegenerative disorders. Appropriate levels of cholesterol are very important for the proper functioning of glutamate transport while unbalanced lev...
| Published in: | Springer eBooks |
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| Main Author: | |
| Corporate Author: | |
| Format: | eBook |
| Language: | English |
| Published: |
New York, NY :
Springer New York : Imprint: Springer,
2013.
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| Series: | SpringerBriefs in Neuroscience,
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| Subjects: | |
| Online Access: | http://dx.doi.org/10.1007/978-1-4614-7759-4 Перейти в каталог НБ ТГУ |
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| 100 | 1 | |a Borisova, Tatiana. |e author. |9 414069 | |
| 245 | 1 | 0 | |a Cholesterol and Presynaptic Glutamate Transport in the Brain |h electronic resource |c by Tatiana Borisova. |
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| 505 | 0 | |a Presynaptic glutamate transport in the brain -- Cholesterol and its role in synaptic transmission -- Effects of cholesterol-depleting agent methyl-b-cyclodextrin (MbCD) on the functional state of brain nerve terminals -- The extracellular level and uptake of glutamate in cholesterol-deficient nerve terminals -- Unstimulated and exocytotic glutamate release from cholesterol-deficient nerve terminals -- Neuroprotection by lowering cholesterol. | |
| 520 | |a Glutamate is the primary excitatory neurotransmitter in the CNS and disturbances in glutamate transport contribute to a number of neurological and neurodegenerative disorders. Appropriate levels of cholesterol are very important for the proper functioning of glutamate transport while unbalanced levels of cholesterol have been implicated in the pathogenesis of disorders such as stroke, ischemia, traumatic brain injury, and neurotoxicity. In the proposed book, the author presents data from the literature and from her own lab to address the extent to and way in which membrane cholesterol modulates presynaptic glutamate transport and whether lowering the level of cholesterol available can offer some neuroprotective benefits. | ||
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