Cholesterol and Presynaptic Glutamate Transport in the Brain

Glutamate is the primary excitatory neurotransmitter in the CNS and disturbances in glutamate transport contribute to a number of neurological and neurodegenerative disorders.  Appropriate levels of cholesterol are very important for the proper functioning of glutamate transport while unbalanced lev...

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Bibliographic Details
Published in:Springer eBooks
Main Author: Borisova, Tatiana (Author)
Corporate Author: SpringerLink (Online service)
Format: eBook
Language:English
Published: New York, NY : Springer New York : Imprint: Springer, 2013.
Series:SpringerBriefs in Neuroscience,
Subjects:
Online Access:http://dx.doi.org/10.1007/978-1-4614-7759-4
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Table of Contents:
  • Presynaptic glutamate transport in the brain
  • Cholesterol and its role in synaptic transmission
  • Effects of cholesterol-depleting agent methyl-b-cyclodextrin (MbCD) on the functional state of brain nerve terminals
  • The extracellular level and uptake of glutamate in cholesterol-deficient nerve terminals
  • Unstimulated and exocytotic glutamate release from cholesterol-deficient nerve terminals
  • Neuroprotection by lowering cholesterol.