p53 in the Clinics
With over 60,000 referenced publications, p53 has emerged as one of the most important factors in human cancer. Research on p53 has led to a complete overhaul of our understanding of the molecular basis of human cancer. In recent years, these major advances in knowledge are starting to impact on can...
| Published in: | Springer eBooks |
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| Corporate Author: | |
| Other Authors: | , , |
| Format: | eBook |
| Language: | English |
| Published: |
New York, NY :
Springer New York : Imprint: Springer,
2013.
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| Subjects: | |
| Online Access: | http://dx.doi.org/10.1007/978-1-4614-3676-8 Перейти в каталог НБ ТГУ |
Table of Contents:
- Foreword
- p53 activities and the hallmarks of cancer
- The inheritance of p53
- p53: Guardian of the metabolome
- The p53 family and stem cell biology
- Mutant p53-driven tumorigenesis
- Humanized p53 mouse models
- p53 models for mammary carcinogenesis
- TP53 somatic mutations: Prognostic and predictive value in human cancers
- Assessing TP53 status in human tumors - lessons from breast cancer
- TP53 germline mutations: Genetics of Li-Fraumeni Syndrome
- TP53 gene therapy
- Upstream targets in the p53 pathway
- p53-reactivating molecules as research tools and anti-cancer drugs
- Restoring mutant p53 activity
- p53-immunotherapy of cancer
- Designing p53 trials: a surgical oncologist view
- p53 in the clinic: a pathologist view
- p53 in genetic counseling
- Index.