Homocysteine in Protein Structure/Function and Human Disease Chemical Biology of Homocysteine-containing Proteins /

Homocysteine in Protein Structure/Function and Human Disease Chemical Biology of Homocysteine-containing Proteins /

Excess of homocysteine, a product of the metabolism of the essential amino acid methionine, is associated with poor health, is linked to heart and brain diseases in general human populations, and accelerates mortality in heart disease patients. Neurological and cardiovascular abnormalities occur in...

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Bibliographic Details
Published in:Springer eBooks
Main Author: Jakubowski, Hieronim (Author)
Corporate Author: SpringerLink (Online service)
Format: eBook
Language:English
Published: Vienna : Springer Vienna : Imprint: Springer, 2013.
Subjects:
Life Sciences.
Metabolic diseases.
Biochemistry.
Protein Structure.
Protein Science.
Biochemistry, general.
Medical Biochemistry.
Metabolic Diseases.
Online Access:http://dx.doi.org/10.1007/978-3-7091-1410-0
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Table of Contents:
  • 1. Introduction
  • 2. Homocysteine. Chemical Synthesis
  • Physicochemical Properties
  • Quantification Methods
  • Metabolic Pathways
  • Clinical significance
  • 3. Homocysteine Thiolactone
  • Chemical Synthesis
  • Physicochemical Properties
  • Quantification Methods
  • Biological Formation and Turnover
  • Clinical Significance
  • 4. N-Homocysteinylated Proteins
  • Functional Consequences
  • Albumin
  • Fibrinogen
  • Cytochrome c
  • Other Proteins
  • Quantification Methods
  • Total N-homocysteinylation assays
  • Site-specific N-homocysteinylation assays
  • Formation in vivo
  • Turnover to Nε-Homocysteinyl-lysine
  • Biological Consequences and Clinical Significance
  • 5. S-Homocysteinylated Proteins
  • Formation in vitro
  • Functional Consequences
  • Annexin
  • Metallothionein
  • Fibrilin, Fibronectin, Tropoelastin
  • Detection in vivo
  • Biological consequences
  • Conclusions
  • References.

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