Direct comparison between apparent diffusion coefficient and macromolecular proton fraction as quantitative biomarkers of the human fetal brain maturation
BACKGROUND: Apparent diffusion coefficient (ADC) is known as a quantitative biomarker of prenatal brain maturation. Fast macromolecular proton fraction (MPF) mapping is an emerging method for quantitative assessment of myelination that was recently adapted to fetal MRI.PURPOSE:To compare the capabil...
| Опубликовано в: : | Journal of magnetic resonance imaging Vol. 50, № 1. P. 52-61 |
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| Другие авторы: | , , , |
| Формат: | Статья в журнале |
| Язык: | English |
| Предметы: | |
| Online-ссылка: | http://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000673875 Перейти в каталог НБ ТГУ |
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| 024 | 7 | |a 10.1002/jmri.26635 |2 doi | |
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| 039 | 9 | |a 202001271310 |c 202001211548 |d VLOAD |y 202001211543 |z Александр Эльверович Гилязов | |
| 040 | |a RU-ToGU |b rus |c RU-ToGU | ||
| 245 | 1 | 0 | |a Direct comparison between apparent diffusion coefficient and macromolecular proton fraction as quantitative biomarkers of the human fetal brain maturation |c A. M. Korostyshevskaya, I. Yu. Prihod'ko, A. A. Savelov, V. L. Yarnykh |
| 504 | |a Библиогр.: 44 назв. | ||
| 520 | 3 | |a BACKGROUND: Apparent diffusion coefficient (ADC) is known as a quantitative biomarker of prenatal brain maturation. Fast macromolecular proton fraction (MPF) mapping is an emerging method for quantitative assessment of myelination that was recently adapted to fetal MRI.PURPOSE:To compare the capability of ADC and MPF to quantify the normal fetal brain development.STUDY TYPE:Prospective.POPULATION:Forty-two human fetuses in utero (gestational age [GA] = 27.7 ± 6.0, range 20-38 weeks).FIELD STRENGTH/SEQUENCE: 1.5 T; diffusion-weighted single-shot echo-planar spin-echo with five b-values for ADC mapping; spoiled multishot echo-planar gradient-echo with T1 , proton density, and magnetization transfer contrast weightings for single-point MPF mapping. ASSESSMENT: Two operators measured ADC and MPF in the medulla, pons, cerebellum, thalamus, and frontal, occipital, and temporal cerebral white matter (WM). STATISTICAL TESTS: Mixed repeated-measures analysis of variance (ANOVA) with the factors of pregnancy trimester and brain structure; Pearson correlation coefficient (r); Hotelling-Williams test to compare strengths of correlations. RESULTS: From the 2nd to 3rd trimester, ADC significantly decreased in the thalamus and cerebellum (P < 0.005). MPF significantly increased in the medulla, pons, thalamus, and cerebellum (P < 0.005). Cerebral WM had significantly higher ADC and lower MPF compared with the medulla and pons in both trimesters. MPF (r range 0.83, 0.89, P < 0.001) and ADC (r range -0.43, -0.75, P ≤ 0.004) significantly correlated with GA and each other (r range -0.32, -0.60, P ≤ 0.04) in the medulla, pons, thalamus, and cerebellum. No significant correlations or distinctions between regions and trimesters were observed for cerebral WM (P range 0.1-0.75). Correlations with GA were significantly stronger for MPF compared with ADC in the medulla, pons, and cerebellum (Hotelling-Williams test, P < 0.003) and similar in the thalamus. Structure-averaged MPF and ADC values strongly correlated (r = 0. | |
| 653 | |a количественные биомаркеры | ||
| 653 | |a макромолекулярная протонная фракция | ||
| 653 | |a кажущийся коэффициент диффузии | ||
| 653 | |a внутриутробное созревание мозга | ||
| 655 | 4 | |a статьи в журналах |9 879358 | |
| 700 | 1 | |a Prihod'ko, Irina Yu. |9 499205 | |
| 700 | 1 | |a Savelov, Andrey A. |9 499206 | |
| 700 | 1 | |a Yarnykh, Vasily L. |9 102903 | |
| 700 | 1 | |a Korostyshevskaya, Alexandra M. |9 499207 | |
| 773 | 0 | |t Journal of magnetic resonance imaging |d 2019 |g Vol. 50, № 1. P. 52-61 |x 1053-1807 | |
| 852 | 4 | |a RU-ToGU | |
| 856 | 4 | |u http://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000673875 | |
| 856 | |y Перейти в каталог НБ ТГУ |u https://koha.lib.tsu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=461333 | ||
| 908 | |a статья | ||
| 999 | |c 461333 |d 461333 | ||