Congenital medulloblastoma: Fetal and postnatal longitudinal observation with quantitative MRI
Congenital medulloblastoma is extremely rare. MRI appearance of this tumor in the fetal brain has not been described. A case of congenital medulloblastoma initially observed by antenatal MRI with postnatal follow-up and treatment is presented. A pregnant female underwent fetal MRI on the 31st gestat...
| Published in: | Clinical imaging Vol. 52. P. 172-176 |
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| Other Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Online Access: | http://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000673991 Перейти в каталог НБ ТГУ |
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| 008 | 200122|2018 ne s a eng dd | ||
| 024 | 7 | |a 10.1016/j.clinimag.2018.06.001 |2 doi | |
| 035 | |a to000673991 | ||
| 039 | 9 | |a 202001281539 |c 202001221543 |d VLOAD |y 202001221532 |z Александр Эльверович Гилязов | |
| 040 | |a RU-ToGU |b rus |c RU-ToGU | ||
| 245 | 1 | 0 | |a Congenital medulloblastoma: Fetal and postnatal longitudinal observation with quantitative MRI |c A. M. Korostyshevskaya, A. A. Savelov, L. I. Papusha и [et al.] |
| 504 | |a Библиогр.: 19 назв. | ||
| 520 | 3 | |a Congenital medulloblastoma is extremely rare. MRI appearance of this tumor in the fetal brain has not been described. A case of congenital medulloblastoma initially observed by antenatal MRI with postnatal follow-up and treatment is presented. A pregnant female underwent fetal MRI on the 31st gestational week for routine indications. Midline cerebellar lesion of ≤2 cm in size with minor T2 hypointensity and T1 hyperintensity was identified. Additionally, quantitative MRI including apparent diffusion coefficient (ADC) and fast macromolecular proton fraction (MPF) mapping was performed. The lesion showed a marked ADC decrease and MPF increase. MPF maps depicted the lesion most conspicuously. After term delivery, a male neonate presented with symptoms of increased intracranial pressure. Postnatal MRI identified obstructive hydrocephalus caused by a large posterior fossa mass. The child was treated by cerebrospinal fluid shunt placement. Follow-up quantitative MRI on the fifth month revealed tumor growth and vivid changes of its tissue contrast associated with brain maturation. The tumor appeared nearly isointense on T1- and T2-weighted images and slightly hypointense on the ADC map. MPF contrast showed the most remarkable change from hyper- to hypointensity due to brain myelination with stable MPF in the tumor. Subsequently, the child underwent partial tumor resection, and currently continues treatment with chemotherapy. The pathological diagnosis was desmoplastic/nodular medulloblastoma. The described case illustrates evolution of the tumor contrast in the course of fetal and postnatal brain development and highlights the added diagnostic value of MPF mapping in fetal and neonatal neuroimaging. | |
| 653 | |a медуллобластома | ||
| 653 | |a врожденные опухоли | ||
| 653 | |a магнитно-резонансная томография | ||
| 653 | |a макромолекулярная протонная фракция | ||
| 653 | |a фетальные клетки | ||
| 655 | 4 | |a статьи в журналах |9 879358 | |
| 700 | 1 | |a Savelov, Andrey A. |9 499206 | |
| 700 | 1 | |a Papusha, Liudmila I. |9 499413 | |
| 700 | 1 | |a Druy, Alexander E. |9 499414 | |
| 700 | 1 | |a Yarnykh, Vasily L. |9 102903 | |
| 700 | 1 | |a Korostyshevskaya, Alexandra M. |9 499207 | |
| 773 | 0 | |t Clinical imaging |d 2018 |g Vol. 52. P. 172-176 |x 0899-7071 | |
| 852 | 4 | |a RU-ToGU | |
| 856 | 4 | |u http://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000673991 | |
| 856 | |y Перейти в каталог НБ ТГУ |u https://koha.lib.tsu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=461693 | ||
| 908 | |a статья | ||
| 999 | |c 461693 |d 461693 | ||