Transcriptomic changes triggered by ouabain in rat cerebellum granule cells: Role of α3- and α1-Na+,K+-ATPase-mediated signaling

Transcriptomic changes triggered by ouabain in rat cerebellum granule cells: Role of α3- and α1-Na+,K+-ATPase-mediated signaling

It was shown previously that inhibition of the ubiquitous α1 isoform of Na+,K+-ATPase by ouabain sharply affects gene expression profile via elevation of intracellular [Na+]i/[K+]i ratio. Unlike other cells, neurons are abundant in the α3 isoform of Na+,K+-ATPase, whose affinity in rodents to ouabai...

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Bibliographic Details
Published in:PLoS ONE Vol. 14, № 9. P. e0222767 (1-23)
Other Authors: Shiyan, Alexandra A., Kapilevich, Leonid V. 1963-, Lopachev, Alexander V., Fedorova, Tatiana N., Klementieva, Tatiana S., Moskovtsev, Aleksey A., Kubatiev, Aslan A., Orlov, Sergei N., Smolyaninova, Larisa V.
Format: Article
Language:English
Subjects:
транскриптомные изменения
гранулярные клетки
мозжечок
статьи в журналах
Online Access:http://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000707358
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