Can we improve vaginal tissue healing using customized devices: 3D printing and biomechanical changes in vaginal tissue
BACKGROUND: Determining biomechanical changes in vaginal tissue with tissue stretch is critical for understanding the role of mechanotransduction on vaginal tissue healing. Noncontact dynamic optical coherence elastography (OCE) can quantify biomechanical changes in vaginal tissues noninvasively. Im...
| Published in: | Gynecologic and obstetric investigation Vol. 84, № 2. P. 145-153 |
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| Other Authors: | , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Online Access: | http://vital.lib.tsu.ru/vital/access/manager/Repository/koha:000565134 Перейти в каталог НБ ТГУ |
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| 245 | 1 | 0 | |a Can we improve vaginal tissue healing using customized devices: 3D printing and biomechanical changes in vaginal tissue |c J. Hakim, P. A. Smith, M. Singh [et al.] |
| 336 | |a Текст | ||
| 337 | |a электронный | ||
| 504 | |a Библиогр.: 35 назв. | ||
| 520 | 3 | |a BACKGROUND: Determining biomechanical changes in vaginal tissue with tissue stretch is critical for understanding the role of mechanotransduction on vaginal tissue healing. Noncontact dynamic optical coherence elastography (OCE) can quantify biomechanical changes in vaginal tissues noninvasively. Improved vaginal tissue healing will reduce postoperative complications from vaginal surgery. AIMS:(1) To complete dimensional assessments (DAs) of the vaginal tract. (2) To elucidate biomechanical properties (BMP) of porcine vaginal tissues (PVT). (3) Compare BMPs of piglet and adult PVTs after placement of customized vaginal dilators (VD) by OCE and uniaxial mechanical testing (MT).METHODS:Pilot study using adult nulliparous pig and piglet PVTs (n = 20 each). DA of PVTs was performed using silicone molding. 3D-printed VDs were used to achieve different Relative Diameter Change (RDC) of the PVTs (no dilatation, and -50%, 0%, 50% RDC). Elastographic testing using OCE and MT.RESULTS:Using OCE, no significant differences (SD) were noted between adult and piglet PVT (p = 0.74) or by stretch direction (p = 0.300). SD was noted with increasing RDC (p = 0.023). Using MT, there were SD in tissue stiffness between adult and piglet PVT (p = 0.048), but no SD as a function of RDC (p = 0.750) or stretch direction (p = 0.592).CONCLUSIONS:This study quantified biomechanical changes in PVT with customized stretching by 3D printed VD using both OCE and MT. This work has implications for the mechanotransduction of vaginal wound healing and noninvasive assessment of vaginal diseases. | |
| 653 | |a 3D-печать | ||
| 653 | |a оптическая когерентная эластография | ||
| 653 | |a заживление тканей | ||
| 653 | |a вагина | ||
| 655 | 4 | |a статьи в журналах |9 879358 | |
| 700 | 1 | |a Hakim, Julie |9 563608 | |
| 700 | 1 | |a Smith, P. Alex |9 563610 | |
| 700 | 1 | |a Singh, Manmohan |9 153788 | |
| 700 | 1 | |a Han, Zhaolong |9 153787 | |
| 700 | 1 | |a Raghunathan, Raksha |9 335901 | |
| 700 | 1 | |a Wyman, Omar |9 563611 | |
| 700 | 1 | |a Guffey, Danielle |9 563612 | |
| 700 | 1 | |a Larin, Kirill V. |9 153792 | |
| 700 | 1 | |a Cohn, William |9 563613 | |
| 700 | 1 | |a Dietrich, Jennifer E. |9 447112 | |
| 773 | 0 | |t Gynecologic and obstetric investigation |d 2019 |g Vol. 84, № 2. P. 145-153 |x 0378-7346 | |
| 852 | 4 | |a RU-ToGU | |
| 856 | 4 | |u http://vital.lib.tsu.ru/vital/access/manager/Repository/koha:000565134 | |
| 856 | |y Перейти в каталог НБ ТГУ |u https://koha.lib.tsu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=565134 | ||
| 908 | |a статья | ||
| 039 | |z 21 | ||
| 999 | |c 565134 |d 565134 | ||