Влияние микробиоты кишечника пациентов с болезнью Паркинсона на синтез А-синуклеина в клеточной культуре нейробластомы SH-SY5Y
Parkinson's disease is a chronic neurodegenerative disease caused by the destruction of dopaminergic neurons in the substance of the brain, as well as in other parts of the central nervous system. In this disease, there is a violation of the metabolism of the protein alpha-synuclein and its acc...
| Published in: | Перспективы развития фундаментальных наук. Т. 4 : сборник научных трудов XVIII Международной конференции студентов, аспирантов и молодых ученых, 27-30 апреля 2021 г. Т. 4 : Биология и фундаментальная медицина. С. 40-42 |
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| Other Authors: | , |
| Format: | Book Chapter |
| Language: | Russian |
| Subjects: | |
| Online Access: | http://vital.lib.tsu.ru/vital/access/manager/Repository/koha:000846779 Перейти в каталог НБ ТГУ |
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| 100 | 1 | |a Иккерт, Ольга Павловна |9 92725 | |
| 245 | 1 | 0 | |a Влияние микробиоты кишечника пациентов с болезнью Паркинсона на синтез А-синуклеина в клеточной культуре нейробластомы SH-SY5Y |c О. П. Иккерт, О. Я. Брикунова, В. А. Петров |
| 246 | 1 | 1 | |a Determination of the cytotoxic effect of microorganisms isolated from patients with Parkinson's disease on the cellular U251 Line |
| 336 | |a Текст | ||
| 337 | |a электронный | ||
| 504 | |a Библиогр.: 10 назв. | ||
| 520 | 3 | |a Parkinson's disease is a chronic neurodegenerative disease caused by the destruction of dopaminergic neurons in the substance of the brain, as well as in other parts of the central nervous system. In this disease, there is a violation of the metabolism of the protein alpha-synuclein and its accumulation in neurons leads to the formation of protein complexes, cytoplasmic Lewy bodies. In vitro, on the SH-SY5Y human neuroblastoma cell line, the effect of different physiological groups of bacteria isolated in enrichment cultures from the microbiome of patients with Parkinson's disease was investigated to increase or decrease the level of a-synuclein expression. Our study showed a positive effect of probiotic cultures containing representatives of the genera Lactobacillus, Enterococcus, Bifidobacterium, in reducing the level of a-synuclein in cultured human neuroblastoma SH-SY5Y. While microorganisms of the genera Clostridium, Tissierella / Soehngenia, Eggerthella, on the contrary, increase the expression of this protein and, probably, accelerate the development of the disease and aggravate the symptoms of the disease. | |
| 653 | |a Паркинсона болезнь | ||
| 653 | |a микробиота кишечника | ||
| 653 | |a синуклеины | ||
| 653 | |a экспериментальные исследования | ||
| 655 | 4 | |a статьи в сборниках |9 879352 | |
| 700 | 1 | |a Брикунова, Ольга Ярославовна |9 794843 | |
| 700 | 1 | |a Петров, Вячеслав Алексеевич |9 794844 | |
| 773 | 0 | |t Перспективы развития фундаментальных наук. Т. 4 : сборник научных трудов XVIII Международной конференции студентов, аспирантов и молодых ученых, 27-30 апреля 2021 г. |d Томск, 2021 |g Т. 4 : Биология и фундаментальная медицина. С. 40-42 |z 9785438710141 |z 9785438710103 | |
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| 908 | |a статья | ||
| 039 | |z 100 | ||
| 999 | |c 846779 |d 846779 | ||