Premalignant changes in the bronchial epithelium are prognostic factors of distant metastasis in non-small cell lung cancer patients
Background: The study assessed the possibility of dividing patients into groups based on the assessment of morphological changes in the epithelium of small-caliber bronchi located near the primary tumor in order to predict high and low risks of distant metastasis of non-small cell lung cancer. Metho...
| Published in: | Frontiers in oncology Vol. 11. P. 771802 (1-10) |
|---|---|
| Other Authors: | , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Online Access: | http://vital.lib.tsu.ru/vital/access/manager/Repository/koha:000896153 Перейти в каталог НБ ТГУ |
| LEADER | 03300nab a2200457 c 4500 | ||
|---|---|---|---|
| 001 | koha000896153 | ||
| 005 | 20230320001932.0 | ||
| 007 | cr | | ||
| 008 | 220614|2021 sz s a eng d | ||
| 024 | 7 | |a 10.3389/fonc.2021.771802 |2 doi | |
| 035 | |a koha000896153 | ||
| 040 | |a RU-ToGU |b rus |c RU-ToGU | ||
| 245 | 1 | 0 | |a Premalignant changes in the bronchial epithelium are prognostic factors of distant metastasis in non-small cell lung cancer patients |c O. V. Pankova, L. A. Tashireva, E. O. Rodionov [et al.] |
| 336 | |a Текст | ||
| 337 | |a электронный | ||
| 504 | |a Библиогр.: 11 назв. | ||
| 520 | 3 | |a Background: The study assessed the possibility of dividing patients into groups based on the assessment of morphological changes in the epithelium of small-caliber bronchi located near the primary tumor in order to predict high and low risks of distant metastasis of non-small cell lung cancer. Methods: In 171 patients with non-small cell lung cancer (T1-4N0-3M0) in small-caliber bronchi taken at a distance of 3-5 cm from the tumor, various variants of morphological changes in the bronchial epithelium (basal cell hyperplasia (BCH), squamous cell metaplasia (SM), and dysplasia (D)) were assessed. Long-term results of treatment, namely, distant metastasis, were assessed after 2 and 5 years. Results: During the follow-up period, distant metastases were found in 35.1% (60/171) of patients. Most often, they were observed in patients of the high-risk group: BCH+SM−D−(51.6%, 40/95) and BCH−SM+D+ (54.4%, 6/11). Less often, distant metastases were observed in low-risk group patients: BCH+SM+D− (6.7%, 3/45) and BCH−SM−D−(10.0%, 2/20). Tumor size, grade, and stage were significant predictors of metastasis only in the high-risk group. The 5-year metastasis-free survival was better in the low-risk group of distant metastases. Conclusions: Isolated BCH or dysplasia in small bronchi distant from foci of tumor isassociated with a high-risk distant metastasis and less 5-year metastasis-free survival. | |
| 653 | |a немелкоклеточный рак легкого | ||
| 653 | |a поражение бронхов | ||
| 653 | |a отдаленные метастазы | ||
| 653 | |a безметастатическая выживаемость | ||
| 653 | |a плоскоклеточная метаплазия | ||
| 655 | 4 | |a статьи в журналах |9 879358 | |
| 700 | 1 | |a Pankova, Olga V. |9 807144 | |
| 700 | 1 | |a Tashireva, Liubov A. |9 208091 | |
| 700 | 1 | |a Rodionov, Evgeniy O. |9 806749 | |
| 700 | 1 | |a Miller, Sergey V. |9 807146 | |
| 700 | 1 | |a Tuzikov, Sergey A. |9 807147 | |
| 700 | 1 | |a Pismenny, Dmitry S. |9 807148 | |
| 700 | 1 | |a Gerashchenko, Tatiana S. |9 96117 | |
| 700 | 1 | |a Zavyalova, Marina V. |9 96115 | |
| 700 | 1 | |a Vtorushin, Sergey V. |9 295269 | |
| 700 | 1 | |a Denisov, Evgeny V. |9 96114 | |
| 700 | 1 | |a Perelmuter, Vladimir M. |9 96116 | |
| 773 | 0 | |t Frontiers in oncology |d 2021 |g Vol. 11. P. 771802 (1-10) |x 2234-943X | |
| 852 | 4 | |a RU-ToGU | |
| 856 | 4 | |u http://vital.lib.tsu.ru/vital/access/manager/Repository/koha:000896153 | |
| 856 | |y Перейти в каталог НБ ТГУ |u https://koha.lib.tsu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=896153 | ||
| 908 | |a статья | ||
| 039 | |z 124 | ||
| 999 | |c 896153 |d 896153 | ||