Optical coherence microangiography of the mouse kidney for diagnosis of circulatory disorders

Optical coherence tomography (OCT) has become widespread in clinical applications in which precise three-dimensional functional imaging of living organs is required. Nevertheless, the kidney is inaccessible for the high resolution OCT imaging due to a high light attenuation coefficient of skin and s...

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Published in:Biomedical optics express Vol. 12, № 7. P. 4467-4477
Other Authors: Abdurashitov, Arkady S., Prikhozhdenko, Ekaterina S., Mayorova, Oksana A., Plastun, Valentina O., Gusliakova, Olga I., Shushunova, Natalia A., Kulikov, Oleg A., Tuchin, Valery V., Sukhorukov, Gleb B., Sindeeva, Olga A.
Format: Article
Language:English
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Online Access:http://vital.lib.tsu.ru/vital/access/manager/Repository/koha:000925623
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245 1 0 |a Optical coherence microangiography of the mouse kidney for diagnosis of circulatory disorders  |c A. S. Abdurashitov, E. S. Prikhozhdenko, O. A. Mayorova [et al.] 
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520 3 |a Optical coherence tomography (OCT) has become widespread in clinical applications in which precise three-dimensional functional imaging of living organs is required. Nevertheless, the kidney is inaccessible for the high resolution OCT imaging due to a high light attenuation coefficient of skin and soft tissues that significantly limits the penetration depth of the probing laser beam. Here, we introduce a surgical protocol and fixation scheme that enables functional visualization of kidney's peritubular capillaries via OCT microangiography. The model of reversible/irreversible glomerulus embolization using drug microcarriers confirms the ability of OCT to detect circulatory disorders. This approach can be used for choosing optimal carriers, their dosages and diagnosis of other blood flow pathologies. 
653 |a оптическая когерентная томография-ангиография 
653 |a диагностика нарушений кровообращения 
655 4 |a статьи в журналах  |9 879358 
700 1 |a Abdurashitov, Arkady S.  |9 803850 
700 1 |a Prikhozhdenko, Ekaterina S.  |9 489754 
700 1 |a Mayorova, Oksana A.  |9 506778 
700 1 |a Plastun, Valentina O.  |9 854968 
700 1 |a Gusliakova, Olga I.  |9 806651 
700 1 |a Shushunova, Natalia A.  |9 486533 
700 1 |a Kulikov, Oleg A.  |9 806652 
700 1 |a Tuchin, Valery V.  |9 78712 
700 1 |a Sukhorukov, Gleb B.  |9 113431 
700 1 |a Sindeeva, Olga A.  |9 803846 
773 0 |t Biomedical optics express  |d 2021  |g Vol. 12, № 7. P. 4467-4477  |x 2156-7085 
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