In vivo quantification of the effectiveness of topical low-dose photodynamic therapy in wound healing using two-photon microscopy
The effect of low-dose photodynamic therapy on in vivo wound healing with topical application of 5-aminolevulinic acid and methylene blue was investigated using an animal model for two laser radiation doses (1 and 4 J/cm2). A second-harmonic-generation-to-auto-fluorescence aging index of the dermis...
| Published in: | Pharmaceutics Vol. 14, № 2. P. 287 (1-17) |
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| Other Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Online Access: | http://vital.lib.tsu.ru/vital/access/manager/Repository/koha:000926715 Перейти в каталог НБ ТГУ |
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| 245 | 1 | 0 | |a In vivo quantification of the effectiveness of topical low-dose photodynamic therapy in wound healing using two-photon microscopy |c H. Zuhayri, V. V. Nikolaev, A. I. Knyazkova [et al.] |
| 336 | |a Текст | ||
| 337 | |a электронный | ||
| 504 | |a Библиогр.: 61 назв. | ||
| 520 | 3 | |a The effect of low-dose photodynamic therapy on in vivo wound healing with topical application of 5-aminolevulinic acid and methylene blue was investigated using an animal model for two laser radiation doses (1 and 4 J/cm2). A second-harmonic-generation-to-auto-fluorescence aging index of the dermis (SAAID) was analyzed by two-photon microscopy. SAAID measured at 60-80 μm depths was shown to be a suitable quantitative parameter to monitor wound healing. A comparison of SAAID in healthy and wound tissues during phototherapy showed that both light doses were effective for wound healing; however, healing was better at a dose of 4 J/cm2. | |
| 653 | |a лечение раны | ||
| 653 | |a фотодинамическая терапия | ||
| 653 | |a низкие дозы | ||
| 653 | |a фотосенсибилизаторы | ||
| 653 | |a двухфотонная микроскопия | ||
| 653 | |a генерация второй гармоники | ||
| 653 | |a автофлуоресценция | ||
| 655 | 4 | |a статьи в журналах |9 879358 | |
| 700 | 1 | |a Zuhayri, Hala |9 799268 | |
| 700 | 1 | |a Nikolaev, Viktor V. |9 190786 | |
| 700 | 1 | |a Knyazkova, Anastasia I. |9 435055 | |
| 700 | 1 | |a Lepekhina, Tatiana B. |9 855302 | |
| 700 | 1 | |a Krivova, Natalya A. |9 423625 | |
| 700 | 1 | |a Tuchin, Valery V. |9 78712 | |
| 700 | 1 | |a Kistenev, Yury V. |9 99223 | |
| 773 | 0 | |t Pharmaceutics |d 2022 |g Vol. 14, № 2. P. 287 (1-17) |x 1999-4923 | |
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