Solubility in pharmaceutical chemistry
This book describes the physicochemical fundamentals and biomedical principles of drug solubility. Methods to study and predict solubility in silico and in vitro are described and the role of solubility in a medicinal chemistry and pharmaceutical industry context are discussed. Approaches to modify...
| Другие авторы: | , |
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| Формат: | Электронная книга |
| Язык: | English |
| Публикация: |
Berlin ; Boston
Walter de Gruyter GmbH,
[2020]
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| Предметы: | |
| Online-ссылка: | EBSCOhost Перейти в каталог НБ ТГУ |
Оглавление:
- Frontmatter
- Contents
- List of contributors
- 1. Solubility
- definition and basic physicochemical considerations / Elder, David
- 2. Solubility and supersaturation / Bauer-Brandl, Annette / Brandl, Martin
- 3. In Silico methods to predict solubility / McDonagh, James L. / Mitchell, John Bo / Palmer, David S / Skyner, Rachael E.
- 4. How solubility influences bioavailability / Faller, Bernard / Desrayaud, Sandrine / Berghausen, Joerg / Laisney, Marc / Dodd, Stephanie
- 5. Estimation of intraluminal drug solubility / Reppas, Christos / Vertzoni, Maria
- 6. Biorelevant media / Dressman, Jennifer
- 7. The role of solubility to optimize drug substances
- a medicinal chemistry perspective / Saal, Christoph / Valko, Klara
- 8. The role of solubility in optimizing drug products
- a pharmaceutical development perspective / Holm, René
- 9. The relevance of solid-state forms for solubility / Saal, Christoph
- 10. Solubility and phase behaviour from a drug substance manufacturing perspective / Beckmann, Wolfgang
- 11. Biowaivers / Elder, David
- List of Abbreviations
- Index