Cell therapy with human reprogrammed CD8+ T-cells has antimetastatic effects on Lewis lung carcinoma in C57BL/6 mice

Cell therapy with human reprogrammed CD8+ T-cells has antimetastatic effects on Lewis lung carcinoma in C57BL/6 mice

Using a model of Lewis lung carcinoma (LLC) in vitro and in vivo, we previously demonstrated increased antitumor activity in CD8+ T-cells reprogrammed with an MEK inhibitor and PD-1 blocker. In this follow-up study, we carried out the reprogramming of human CD8+ T-cells (hrT-cell) using the MEK inhi...

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Bibliographic Details
Published in:International journal of molecular sciences Vol. 23, № 24. P. 15780 (1-16)
Other Authors: Skurikhin, Evgenii G., Pershina, Olga, Ermakova, Natalia N., Pakhomova, Angelina, Zhukova, Mariia, Pan, Edgar S., Sandrikina, Lyubov A., Widera, Darius, Kogai, Lena, Kushlinskii, Nikolai, Kubatiev, Aslan A., Morozov, Sergey G., Dygai, Alexander M.
Format: Article
Language:English
Subjects:
Льюиса карцинома легких
ксенотрансплантация
мыши
антиметастатическая активность
CD8+Т-клетки
перепрограммирование
статьи в журналах
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