Elevation of intracellular Na+ contributes to expression of early response genes triggered by endothelial cell shrinkage

Elevation of intracellular Na+ contributes to expression of early response genes triggered by endothelial cell shrinkage

BACKGROUND/AIMS: Prolonged hyperosmotic shrinkage evokes expression of osmoprotective genes via nuclear factor NFAT5-mediated pathway and activates Na+ influx via hypertonicity-induced cation channels (HICC). In human umbilical vein endothelial cells (HUVEC) elevation of intracellular sodium concent...

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Bibliographic Details
Published in:Cellular physiology and biochemistry Vol. 53, № 4. P. 638-647
Other Authors: Sidorenko, Svetlana V., Fedorov, Dmitry, Klimanova, Elizaveta A., Smolyaninova, Larisa V., Kapilevich, Leonid V. 1963-, Grygorczyk, Ryszard, Orlov, Sergei N., Shiyan, Alexandra A.
Format: Article
Language:English
Subjects:
эндотелий
гены раннего ответа
внутриклеточная концентрация натрия
одновалентные катионы
статьи в журналах
Online Access:http://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000707359
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http://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000707359
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