NADPH oxidase mediates microtubule alterations and diaphragm dysfunction in dystrophic mice
Skeletal muscle from mdx mice is characterized by increased Nox2 ROS, altered microtubule network, increased muscle stiffness, and decreased muscle/respiratory function. While microtubule de-tyrosination has been suggested to increase stiffness and Nox2 ROS production in isolated single myofibers, i...
| Published in: | eLife Vol. 7. P. e31732 (1-19) |
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| Other Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Online Access: | http://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000628506 Перейти в каталог НБ ТГУ |
| LEADER | 02721nab a2200397 c 4500 | ||
|---|---|---|---|
| 001 | vtls000628506 | ||
| 003 | RU-ToGU | ||
| 005 | 20230319151007.0 | ||
| 007 | cr | | ||
| 008 | 180606|2018 enk s a eng d | ||
| 024 | 7 | |a 10.7554/eLife.31732 |2 doi | |
| 035 | |a to000628506 | ||
| 039 | 9 | |a 201806070916 |c 201806061628 |d VLOAD |y 201806061610 |z Александр Эльверович Гилязов | |
| 040 | |a RU-ToGU |b rus |c RU-ToGU | ||
| 245 | 1 | 0 | |a NADPH oxidase mediates microtubule alterations and diaphragm dysfunction in dystrophic mice |c J. A. Loehr, S. Wang, T. R. Cully [et.al.] |
| 504 | |a Библиогр.: с. e31732 (15-19) | ||
| 520 | 3 | |a Skeletal muscle from mdx mice is characterized by increased Nox2 ROS, altered microtubule network, increased muscle stiffness, and decreased muscle/respiratory function. While microtubule de-tyrosination has been suggested to increase stiffness and Nox2 ROS production in isolated single myofibers, its role in altering tissue stiffness and muscle function has not been established. Because Nox2 ROS production is upregulated prior to microtubule network alterations and ROS affect microtubule formation, we investigated the role of Nox2 ROS in diaphragm tissue microtubule organization, stiffness and muscle/respiratory function. Eliminating Nox2 ROS prevents microtubule disorganization and reduces fibrosis and muscle stiffness in mdx diaphragm. Fibrosis accounts for the majority of variance in diaphragm stiffness and decreased function, implicating altered extracellular matrix and not microtubule de-tyrosination as a modulator of diaphragm tissue function. Ultimately, inhibiting Nox2 ROS production increased force and respiratory function in dystrophic diaphragm, establishing Nox2 as a potential therapeutic target in Duchenne muscular dystrophy. | |
| 653 | |a микротрубочки | ||
| 653 | |a диафрагма | ||
| 653 | |a Дюшенна мышечная дистрофия | ||
| 653 | |a скелетные мышцы | ||
| 653 | |a НАДФH-оксидаза | ||
| 655 | 4 | |a статьи в журналах |9 879358 | |
| 700 | 1 | |a Loehr, James Anthony |9 173515 | |
| 700 | 1 | |a Cully, Tanya R. |9 173516 | |
| 700 | 1 | |a Pal, Rituraj |9 173517 | |
| 700 | 1 | |a Larina, Irina V. |9 173518 | |
| 700 | 1 | |a Larin, Kirill V. |9 153792 | |
| 700 | 1 | |a Rodney, George G. |9 173519 | |
| 700 | 1 | |a Wang, Shang |9 173520 | |
| 773 | 0 | |t eLife |d 2018 |g Vol. 7. P. e31732 (1-19) |x 2050-084X | |
| 852 | 4 | |a RU-ToGU | |
| 856 | 7 | |u http://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000628506 | |
| 856 | |y Перейти в каталог НБ ТГУ |u https://koha.lib.tsu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=78344 | ||
| 908 | |a статья | ||
| 999 | |c 78344 |d 78344 | ||