Exploration of nitrogen heterocycle scaffolds for the development of potent human neutrophil elastase inhibitors

Exploration of nitrogen heterocycle scaffolds for the development of potent human neutrophil elastase inhibitors

Human neutrophil elastase (HNE) is a potent protease that plays an important physiological role in many processes but is also involved in a variety of pathologies that affect the pulmonary system. Thus, compounds able to inhibit HNE proteolytic activity could represent effective therapeutics. We pre...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry Vol. 29. P. 115836 (1-17)
Other Authors: Cantini, Niccolò, Khlebnikov, Andrei I., Crocetti, Letizia, Schepetkin, Igor A., Floresta, Giuseppe, Guerrini, Gabriella, Vergelli, Claudia, Bartolucci, Gianluca, Quinn, Mark T., Giovannoni, Maria Paola
Format: Article
Language:English
Subjects:
эластаза нейтрофилов
ингибиторы
азотный гетероцикл
молекулярная стыковка
статьи в журналах
Online Access:http://vital.lib.tsu.ru/vital/access/manager/Repository/koha:000923734
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